Cushing syndrome as a presenting symptom of renal tumors in children

H Segers; J C van der Heyden; E L T van den Akker; R R de Krijger; C M Zwaan; M M van den Heuvel-Eibrink

doi:10.1002/pbc.22021

Cushing syndrome as a presenting symptom of renal tumors in children

Pediatr Blood Cancer. 2009 Aug;53(2):211-3. doi: 10.1002/pbc.22021.

Authors

H Segers¹, J C van der Heyden, E L T van den Akker, R R de Krijger, C M Zwaan, M M van den Heuvel-Eibrink

Affiliation

¹ Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.

PMID: 19353619
DOI: 10.1002/pbc.22021

Abstract

Cushing syndrome as the presenting symptom of a malignant renal tumor in children is rare. We report the first case of paraneoplastic Cushing syndrome due to a Wilms tumor, in which clinical and biological signs of hypercortisolism regressed during preoperative chemotherapy. Additionally, we reviewed the literature on paraneoplastic Cushing syndrome secondary to pediatric renal tumors.

Publication types

Case Reports

MeSH terms

Adrenocorticotropic Hormone / blood
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Child, Preschool
Combined Modality Therapy
Cushing Syndrome / etiology*
Female
Humans
Hydrocortisone / blood
Kidney Neoplasms / complications*
Kidney Neoplasms / pathology
Kidney Neoplasms / therapy
Nephrectomy
Paraneoplastic Syndromes / etiology
Radiotherapy
Wilms Tumor / complications*
Wilms Tumor / pathology
Wilms Tumor / therapy

Substances

Adrenocorticotropic Hormone
Hydrocortisone