1 North West Thames Regional Genetics Centre, Northwick Park and St Mark's Hospital, Harrow Oxford Regional Genetics Service, Churchill Hospital, Oxford St Mary's Hospital, London Southwark Children and Young Peoples Development Centre, London West Midlands Regional Genetics Centre, Birmingham Women's Hospital, Edgbaston, Birmingham Nottingham Department of Clinical Genetics, City Hospital, Nottingham, UK Hôpital Necker-Enfantes-Malades, Paris, France.