Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults

Fidéline Collin; Xavier Duval; Vincent Le Moing; Lionel Piroth; Firas Al Kaied; Patrice Massip; Virginie Villes; Geneviève Chêne; François Raffi; ANRS CO8 APROCO-COPILOTE study group

doi:10.1097/QAD.0b013e3283292195

Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults

AIDS. 2009 May 15;23(8):1021-4. doi: 10.1097/QAD.0b013e3283292195.

Authors

Fidéline Collin¹, Xavier Duval, Vincent Le Moing, Lionel Piroth, Firas Al Kaied, Patrice Massip, Virginie Villes, Geneviève Chêne, François Raffi; ANRS CO8 APROCO-COPILOTE study group

Collaborators

ANRS CO8 APROCO-COPILOTE study group:
C Leport, F Raffi, G Chêne, R Salamon, J-P Moatti, J Pierret, B Spire, F Brun-Vézinet, H Fleury, B Masquelier, G Peytavin, R Garraffo, D Costagliola, P Dellamonica, C Katlama, L Meyer, D Salmon, A Sobel, L Cuzin, M Dupon, X Duval, V Le Moing, B Marchou, T May, P Morlat, C Rabaud, A Waldner-Combernoux, F Collin-Filleul, C Perronne, C Lewden, J L Schmit, J M Chennebault, J P Faller, J L Dupond, J M Estavoyer, Drobachef, O Bouchaud, Longy-Boursier, J M Ragnaud, P Granier, M Garré, R Verdon, D Merrien, A Devidas, A Sobel, H Portier, P Lagarde, J Ceccaldi, D Peyramond, C Allard, J Reynes, J G Fuzibet, P Dellamonica, P Arsac, E Bouvet, F Bricaire, P Bergmann, J Cabane, J Monsonego, P M Girard, L Guillevin, S Herson, C Leport, M C Meyohas, J M Molina, G Pialoux, D Salmon, B Becq-Giraudon, R Jaussaud, C Michelet, F Lucht, T Debord, J M Lang, J P De Jaureguiberry, B Marchou, J M Besnier, J Biemar, S Boucherit, A D Bouhnik, C Brunet-François, M P Carrieri, F Couturier, J L Ecobichon, V Guiyedi, P Kurkdji, S Martiren, M Préau, C Protopopescu, C Roy, J Surzyn, A Taieb, V Villes, C Wallet

Affiliation

¹ INSERM U 897, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, case 11, 33076 Bordeaux Cedex, France. Fideline.Collin@isped.u-bordeaux2.fr

Abstract

In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone fractures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0-4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with excessive alcohol consumption and 3.6-fold (95% CI = 1.6-8.1) higher in those with hepatitis C virus (HCV) coinfection. Specific monitoring of HCV/HIV-coinfected patients and active promotion of alcohol cessation should be recommended for the prevention of bone fractures.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alcohol Drinking / epidemiology*
Cohort Studies
Drug Therapy, Combination
Female
Fractures, Bone / epidemiology*
France / epidemiology
HIV Infections / epidemiology*
HIV-1*
Hepatitis C / epidemiology*
Humans
Incidence
Male
RNA, Viral
Risk Factors

Substances

RNA, Viral