Efficient system for the preparation of [13N]labeled nitrosamines

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1913-5. doi: 10.1016/j.bmcl.2009.02.066. Epub 2009 Feb 21.

Abstract

In the present Letter, a fast and reproducible method for the synthesis of N-[(13)N]nitrosamines is reported. The labeling strategy is based on trapping [(13)N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph(3)P and Br(2) led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Isotope Labeling / methods*
  • Nitrogen Radioisotopes / chemistry
  • Nitrogen Radioisotopes / isolation & purification
  • Nitrosamines / chemical synthesis*
  • Nitrosamines / chemistry
  • Nitrosamines / isolation & purification

Substances

  • Nitrogen Radioisotopes
  • Nitrosamines