A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype

Igor B Kuznetsov; Michael McDuffie; Roxana Moslehi

doi:10.1093/bioinformatics/btp121

A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype

Bioinformatics. 2009 May 1;25(9):1185-6. doi: 10.1093/bioinformatics/btp121. Epub 2009 Mar 4.

Authors

Igor B Kuznetsov¹, Michael McDuffie, Roxana Moslehi

Affiliation

¹ Gen*NY*Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA. ikuznetsov@albany.edu

Abstract

N-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server can be used for a fast determination of NAT2 phenotypes in genetic screens.

Availability: Freely available at http://nat2pred.rit.albany.edu.

Supplementary information: Supplementary data are available at Bioinformatics online.

MeSH terms

Arylamine N-Acetyltransferase / classification
Arylamine N-Acetyltransferase / genetics*
Arylamine N-Acetyltransferase / metabolism
Genotype
Humans
Internet
Phenotype
Polymorphism, Single Nucleotide*
Software*
Substrate Specificity

Substances

Arylamine N-Acetyltransferase
NAT2 protein, human