Retrograde transcatheter aortic valve implantation (TAVI) was successfully performed in an 80-year-old woman who had critical aortic stenosis but had no conventional access available because of severe calcifications of the femoral, iliac, and subclavian arteries. The TAVI procedure was performed with the CoreValve ReValving System. The currently available results obtained with TAVI show that such approaches provide significant clinical improvement in patients with severe aortic stenosis and unacceptable risk or contraindications for surgery. The ascending aorta approach might help to expand the implantation possibilities for those patients for whom the typical access sites are not available.