Osteoid osteoma is a benign bone tumor traditionally treated nonoperatively or by operative excision. However, radiofrequency ablation (RFA) is being used increasingly for treatment of osteoid osteoma, as there are several reports supporting its effectiveness. We present a case of osteoid osteoma of femur in an 18-year-old boy. The patient complained of pain in right hip and knee joint. The osteoid osteoma lesion was successfully treated by percutaneous computed tomography (CT)-guided RFA using the cool-tip RFA system under general anesthesia. He had total pain relief within 24 hours following the procedure. No complications were recorded. He discharged on foot two days after RFA therapy. Complete regression of symptoms was observed at 2-year follow-up. CT-guided RFA for osteoid osteoma is a safe, effective and minimally invasive procedure with high success rate and lack of relapse.