Enantioselective oxidation of racemic lactic acid to D-lactic acid and pyruvic acid by Pseudomonas stutzeri SDM

Bioresour Technol. 2009 Mar;100(5):1878-80. doi: 10.1016/j.biortech.2008.09.053. Epub 2008 Nov 11.

Abstract

D-lactic acid and pyruvic acid are two important building block intermediates. Production of D-lactic acid and pyruvic acid from racemic lactic acid by biotransformation is economically interesting. Biocatalyst prepared from 9 g dry cell wt l(-1) of Pseudomonas stutzeri SDM could catalyze 45.00 g l(-1)DL-lactic acid into 25.23 g l(-1)D-lactic acid and 19.70 g l(-1) pyruvic acid in 10h. Using a simple ion exchange process, D-lactic acid and pyruvic acid were effectively separated from the biotransformation system. Co-production of d-lactic acid and pyruvic acid by enantioselective oxidation of racemic lactic acid is technically feasible.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biotechnology / methods*
  • Biotransformation
  • Catalysis
  • Lactic Acid / metabolism*
  • Oxidation-Reduction
  • Pseudomonas stutzeri / metabolism*
  • Pyruvic Acid / metabolism*

Substances

  • Lactic Acid
  • Pyruvic Acid