Abstract
A new compound, euparvic acid (1, C(14)H(16)O(6)), and the known compounds 5,7-dihydroxy-4-methylphthalide (2), 6-(3-carboxybutyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (3), 6-(5-carboxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (4), and 6-(5-carboxy-4-hydroxy-3-methylpent-2-enyl)-7-hydroxy-5-methoxy-4-methylphthalan-1-one (5) were isolated from the EtOAc extract of Eupenicillium parvum. The structure of 1 was determined by interpretation of MS and homo- and heteronuclear 2D NMR spectroscopic data and confirmed by X-ray crystallography. The absolute configuration of 5 was determined via MPA ester derivatization.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Aspergillus fumigatus / drug effects
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Crystallography, X-Ray
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Escherichia coli / drug effects
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Eupenicillium / chemistry*
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Microbial Sensitivity Tests
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Molecular Conformation
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Molecular Structure
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Mycophenolic Acid* / analogs & derivatives
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Mycophenolic Acid* / chemistry
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Mycophenolic Acid* / isolation & purification
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Pseudomonas aeruginosa / drug effects
Substances
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Anti-Bacterial Agents
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euparvic acid
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Mycophenolic Acid