Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population

Heart. 2008 Nov;94(11):1394-6. doi: 10.1136/hrt.2008.148544.

Abstract

Background: Atrial fibrillation (AF) and atrial flutter (AFL) are common cardiac conduction disorders affecting many people. Recent studies on sporadic cases of AF/AFL showed a significant association of the single nucleotide polymorphism rs2200733T with the disease, suggesting a genetic factor in the development of the disease.

Objectives: To determine the association of rs2200733 with AF/AFL derived from an Italian population sample.

Subjects: 78 patients with AF/AFL and 348 controls took part in the study.

Design: Genetic case-control study.

Results: The results indicate that there is a positive, significant association between the rs2200733 T allele and patients with AF/AFL of Italian origin (allelic p<0.001 with OR = 2.17).

Conclusion: These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arrhythmias, Cardiac / genetics*
  • Arrhythmias, Cardiac / physiopathology
  • Atrial Fibrillation / genetics*
  • Atrial Flutter / genetics*
  • Case-Control Studies
  • Chromosomes, Human, Pair 4 / genetics*
  • Electrocardiography
  • Female
  • Genetic Linkage
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide / genetics*