Familial narcolepsy in Finland

Acta Neurol Scand. 1991 Jun;83(6):388-93. doi: 10.1111/j.1600-0404.1991.tb03969.x.

Abstract

Five patients with narcolepsy-cataplexy (aged 31-69, mean age at onset 15 years) and their 47 relatives were examined. They were interviewed in detail, all patients and 16 relatives (including all symptomatic cases) were examined neurologically and a multiple sleep latency test and HLA-typing were done. One case of narcolepsy and two cases of idiopathic hypersomnia were identified. All the other 45 relatives were symptom-free. The observed rate of familial cases (1/5 for narcolepsy and 2/5 for idiopathic hypersomnia) corresponds the results of other recent studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Disorders of Excessive Somnolence / diagnosis
  • Disorders of Excessive Somnolence / genetics
  • Electroencephalography
  • Female
  • HLA-DR2 Antigen / genetics
  • Humans
  • Male
  • Middle Aged
  • Narcolepsy / diagnosis
  • Narcolepsy / genetics*
  • Neurologic Examination
  • Pedigree
  • Reaction Time / genetics
  • Sleep Stages / genetics

Substances

  • HLA-DR2 Antigen