Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

Nat Genet. 2008 Oct;40(10):1153-5. doi: 10.1038/ng.214. Epub 2008 Aug 31.

Abstract

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Chromosome Mapping
  • Chromosomes, Human, Pair 17 / genetics*
  • Genetic Linkage
  • Genetic Predisposition to Disease / genetics*
  • Haplotypes / genetics*
  • Hepatocyte Nuclear Factor 1-beta / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / pathology
  • Risk Factors

Substances

  • HNF1B protein, human
  • Hepatocyte Nuclear Factor 1-beta