Community-associated methicillin-resistant Staphylococcus aureus infective endocarditis with Panton-Valentine leukocidin gene in an injection drug user with HIV infection

Intern Med. 2008;47(16):1485-9. doi: 10.2169/internalmedicine.47.0878. Epub 2008 Aug 15.

Abstract

Reports of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates carrying Panton-Valentine leukocidin (PVL) gene that causes infective endocarditis in injection drug users (IDUs) with human immunodeficiency virus (HIV) infection are rare in the English language literature. We present a case of CA-MRSA infective endocarditis with bilateral septic lung emboli in a previously healthy 45-year-old IDU. This case suggests that PVL gene-positive CA-MRSA should be considered as a potential pathogen in IDUs with infective endocarditis.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Toxins / genetics*
  • Community-Acquired Infections / complications*
  • Community-Acquired Infections / drug therapy
  • Community-Acquired Infections / microbiology
  • Endocarditis, Bacterial / diagnosis*
  • Endocarditis, Bacterial / etiology*
  • Endocarditis, Bacterial / microbiology
  • Exotoxins / genetics*
  • HIV Infections*
  • Humans
  • Leukocidins / genetics*
  • Male
  • Methicillin / therapeutic use
  • Methicillin Resistance
  • Middle Aged
  • Staphylococcal Infections / complications*
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / pathogenicity
  • Substance Abuse, Intravenous*

Substances

  • Anti-Bacterial Agents
  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin
  • Methicillin