Identification of loci associated with schizophrenia by genome-wide association and follow-up

Nat Genet. 2008 Sep;40(9):1053-5. doi: 10.1038/ng.201.

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bipolar Disorder / genetics
  • Case-Control Studies
  • Chromosome Mapping
  • Follow-Up Studies
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study*
  • Humans
  • Kruppel-Like Transcription Factors / genetics*
  • Polymorphism, Single Nucleotide
  • Schizophrenia / genetics*

Substances

  • Kruppel-Like Transcription Factors
  • ZNF804A protein, human