Bone remodelling after growth factor and cyclosporine A therapy for aplastic anemia

B A Derfus; M E Csuka; G F Carrera; G A Hanson; R E Smith

Bone remodelling after growth factor and cyclosporine A therapy for aplastic anemia

J Rheumatol. 1991 May;18(5):738-42.

Authors

B A Derfus¹, M E Csuka, G F Carrera, G A Hanson, R E Smith

Affiliation

¹ Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.

PMID: 1865422

Abstract

We describe a patient with viral induced aplastic anemia who developed severe bone pain after treatment with multiple courses of antithymocyte globulin, cyclosporine A, recombinant human granulocyte macrophage colony stimulating factor and deferoxamine. Radiographs and bone biopsy revealed extensive new trabecular bone formation in long bone diaphyses and adjacent periosteal reaction. The effects of hematopoietic growth factors, cyclosporine A and deferoxamine on bone metabolism are reviewed.

Publication types

Case Reports

MeSH terms

Adolescent
Anemia, Aplastic / diagnostic imaging
Anemia, Aplastic / drug therapy*
Anemia, Aplastic / pathology
Antilymphocyte Serum / therapeutic use
Bone and Bones / diagnostic imaging
Bone and Bones / drug effects*
Bone and Bones / pathology
Cyclosporins / therapeutic use*
Deferoxamine / therapeutic use
Female
Fibula / diagnostic imaging
Fibula / drug effects
Fibula / pathology
Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use
Growth Substances / therapeutic use*
Humans
Radiography
Recombinant Proteins / therapeutic use
Tibia / diagnostic imaging
Tibia / drug effects
Tibia / pathology

Substances

Antilymphocyte Serum
Cyclosporins
Growth Substances
Recombinant Proteins
Granulocyte-Macrophage Colony-Stimulating Factor
Deferoxamine