Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1

H K Jang; T Kitazawa; M Ono; Y Kawaguchi; K Maeda; N Yokoyama; Y Tohya; M Niikura; T Mikami

doi:10.1080/03079459608419116

Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1

Avian Pathol. 1996 Mar;25(1):5-24. doi: 10.1080/03079459608419116.

Authors

H K Jang¹, T Kitazawa, M Ono, Y Kawaguchi, K Maeda, N Yokoyama, Y Tohya, M Niikura, T Mikami

Affiliation

¹ Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Tokyo, 113, Japan.

PMID: 18645833
DOI: 10.1080/03079459608419116

Abstract

Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV-expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV-expressed MDV1-gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Co-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC seemed to show no synergistic effect.