A case of 68-aged male with hypopituitarism who suffered from faints and syncope with nauseas, vomiting and a significant body mass decrease, progressing during 3 yr. was presented. Diagnosis of hypopituitarism was established 3 yr. after symptoms onset. Diagnostic problems concerning hypopituitarism were described, indicating consideration of this uncommon disease in differential diagnosis of disorders which major symptoms are faints and syncope.