Fine-mapping at the HTR2A locus reveals multiple episodic memory-related variants

Biol Psychol. 2008 Oct;79(2):239-42. doi: 10.1016/j.biopsycho.2008.06.002. Epub 2008 Jun 14.

Abstract

A functional polymorphism (His452Tyr) in the gene encoding the serotonin 2A receptor (HTR2A) has been previously associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. Here we present data obtained through imputation and fine-mapping showing that multiple loci within HTR2A are significantly associated with human memory performance independently of the His452Tyr polymorphism. Our data support the existence of multiple memory-related loci within HTR2A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain / anatomy & histology
  • Brain / physiology
  • Brain Mapping*
  • Case-Control Studies
  • Female
  • Genotype
  • Histidine / genetics
  • Humans
  • Linkage Disequilibrium
  • Male
  • Memory / physiology*
  • Neuropsychological Tests
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide / genetics*
  • Receptor, Serotonin, 5-HT2A / genetics
  • Tyrosine / genetics
  • Verbal Learning / physiology
  • Young Adult

Substances

  • Receptor, Serotonin, 5-HT2A
  • Tyrosine
  • Histidine