Objective: To summarize Notch, basic helix-loop-helix (bHLH) and Wnt gene signal transduction pathways in the process of differentiation and development of neural stem cells.
Methods: The literature on the gene signal transduction pathway in the process of differentiation and development of neural stem cells was searched and then summarized and analyzed.
Results: The formation of Nervous System resulted from common actions of multi-signal transduction pathways. There may exist a fixed threshold in the complicated selective system among Notch, bHLH and Wnt gene signal transduction pathways.
Conclusion: At present, the specific gene signal transduction pathway of multiplication and differentiation of neural stem cells is still unclear.