Intracerebral small round cell tumor: an unusual case with EWS-WT1 translocation

Pediatr Blood Cancer. 2008 Oct;51(4):545-8. doi: 10.1002/pbc.21648.

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare tumor, seen both in children and young adults with a marked predilection for the peritoneal cavity. Histology showed a small round cell tumor with a fibromyxoïd stroma and immunohistochemistry indicated neural and mesenchymal differentiation, and diagnosis was made by molecular detection of the EWS-WT1 fusion gene product. DSRCT should be considered in the differential diagnosis of intracranial small round cell tumors.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / genetics
  • Brain Neoplasms / metabolism*
  • Child
  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, Pair 22 / genetics
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism*

Substances

  • EWS1-WT1 fusion protein, human
  • Oncogene Proteins, Fusion