Abstract
In this work, it was of interest to synthesize new series of some 2-[(E)-2-furan-2-yl-vinyl]-quinazolin-4(3H)-ones incorporated into pyrazoline, isoxazoline, pyrimidine or pyrimidine-thione ring systems at position-3 of the quinazoline ring. The antimicrobial activity and antiinflammatory effect of some of these compounds were studied.
MeSH terms
-
Animals
-
Anti-Infective Agents / chemical synthesis
-
Anti-Infective Agents / pharmacology*
-
Anti-Inflammatory Agents / chemical synthesis
-
Anti-Inflammatory Agents / pharmacology*
-
Indomethacin / pharmacology
-
Male
-
Microbial Sensitivity Tests
-
Quinazolines / chemical synthesis
-
Quinazolines / pharmacology*
-
Rats
-
Structure-Activity Relationship
Substances
-
Anti-Infective Agents
-
Anti-Inflammatory Agents
-
Quinazolines
-
Indomethacin