Abstract
Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use
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Clinical Trials as Topic
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Disease Progression
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Gene Expression Regulation, Neoplastic
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Humans
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Integrins / antagonists & inhibitors
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Integrins / genetics*
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Integrins / physiology
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Male
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Neoplasm Metastasis
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Neovascularization, Pathologic / genetics
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Prostatic Neoplasms / blood supply
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Prostatic Neoplasms / genetics*
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Prostatic Neoplasms / pathology
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Tumor Burden / genetics
Substances
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Antineoplastic Agents
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Integrins