Failure to detect human papillomavirus sequences at the 3p21 rearrangement site in pleomorphic adenomas

Cancer Genet Cytogenet. 1991 Apr;52(2):187-91. doi: 10.1016/0165-4608(91)90462-4.

Abstract

Eighteen salivary gland pleomorphic adenomas, including nine with a t(3;8)(p21;q12) as the sole chromosome abnormality, were tested for the presence of human papillomavirus (HPV) DNA and for rearrangements of the cellular flanking regions of a HPV 16 integration site mapping to 3p21, as previously described in a cervical carcinoma. In none of the tumors could evidence for either HPV DNA or related sequences, or a rearranged allele of the integration site, be found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / genetics*
  • Adult
  • Aged
  • Base Sequence
  • Blotting, Southern
  • Chromosome Banding
  • Chromosome Mapping
  • Chromosomes, Human, Pair 3*
  • DNA, Neoplasm / genetics
  • DNA, Viral / genetics
  • Female
  • Humans
  • Karyotyping
  • Male
  • Middle Aged
  • Nucleic Acid Hybridization
  • Papillomaviridae / genetics*
  • Salivary Gland Neoplasms / genetics*
  • Translocation, Genetic*

Substances

  • DNA, Neoplasm
  • DNA, Viral