Tenets of PTEN tumor suppression

Leonardo Salmena; Arkaitz Carracedo; Pier Paolo Pandolfi

doi:10.1016/j.cell.2008.04.013

Tenets of PTEN tumor suppression

Cell. 2008 May 2;133(3):403-14. doi: 10.1016/j.cell.2008.04.013.

Authors

Leonardo Salmena¹, Arkaitz Carracedo, Pier Paolo Pandolfi

Affiliation

¹ Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, New Research Building, 330 Brookline Avenue, Boston, MA 02115, USA.

PMID: 18455982
DOI: 10.1016/j.cell.2008.04.013

Abstract

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and regulation, and speculates about how manipulation of PTEN function could be used for cancer therapy.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Genetic Predisposition to Disease
Humans
Neoplasms / genetics
Neoplasms / metabolism
PTEN Phosphohydrolase / genetics
PTEN Phosphohydrolase / metabolism*
Transcription, Genetic

Substances

PTEN Phosphohydrolase