Abstract
We evaluated a novel truncated hygromycin A analog in which the furanose ring was replaced with a 2-fluoro-2-cyclopropylethyl substituent for its activity against multidrug resistant gram-positive bacteria and compared its activity to the activities of linezolid, quinupristin-dalfopristin, and vancomycin. CE-156811 demonstrated robust in vitro activity against gram-positive bacteria that was comparable to that of linezolid.
MeSH terms
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Acetamides / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Cinnamates / chemistry
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Cinnamates / pharmacology*
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Dioxoles / chemistry
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Dioxoles / pharmacology*
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Drug Resistance, Multiple, Bacterial
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / isolation & purification
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / isolation & purification
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Humans
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Hygromycin B / analogs & derivatives*
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Hygromycin B / chemistry
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Hygromycin B / pharmacology
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In Vitro Techniques
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Linezolid
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Microbial Sensitivity Tests
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Molecular Structure
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Oxazolidinones / pharmacology
Substances
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Acetamides
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Anti-Bacterial Agents
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CE 156811
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Cinnamates
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Dioxoles
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Oxazolidinones
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Hygromycin B
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hygromycin A
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Linezolid