Abstract
Recent advances in molecular genetic techniques are being applied in Dictyostelium to test and expand prevailing views on the functioning of the actin-based cytoskeleton. Current research involves the disruption, by homologous recombination, of genes encoding cytoskeletal elements. We suggest combining classical and molecular genetic approaches to supplement these investigations.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Actins / genetics
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Actins / metabolism
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Animals
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Cloning, Molecular
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Cytoskeletal Proteins / genetics*
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Cytoskeletal Proteins / metabolism
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Cytoskeleton / ultrastructure*
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Dictyostelium / genetics*
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Dictyostelium / ultrastructure
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Fungal Proteins / genetics*
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Fungal Proteins / metabolism
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Gene Expression Regulation, Fungal*
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Genes, Fungal
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Genetic Techniques
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Microfilament Proteins / genetics
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Microfilament Proteins / metabolism
Substances
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Actins
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Cytoskeletal Proteins
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Fungal Proteins
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Microfilament Proteins