Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

Angew Chem Int Ed Engl. 2008;47(20):3747-50. doi: 10.1002/anie.200705795.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkyl and Aryl Transferases / antagonists & inhibitors*
  • Alkyl and Aryl Transferases / chemistry*
  • Alkyl and Aryl Transferases / genetics
  • Animals
  • COS Cells
  • Chlorocebus aethiops
  • Crystallography, X-Ray
  • Drug Design*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Protein Conformation

Substances

  • Enzyme Inhibitors
  • Alkyl and Aryl Transferases
  • Rab geranylgeranyltransferase