Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major

Br J Haematol. 2008 Jun;141(6):891-4. doi: 10.1111/j.1365-2141.2008.07135.x. Epub 2008 Mar 26.

Abstract

Vitamin D25-OH and D1-25OH levels were compared with cardiac R2* (1/T2*), left ventricular ejection fraction (LVEF), age, ferritin and liver iron in 24 thalassaemia major patients. Vitamin D25-OH levels were reduced in 13/24 patients while vitamin D1-25OH levels were often elevated. Vitamin D25-OH levels decreased with age (r(2) = 0.48) and with liver iron (r(2) = 0.20). Cardiac R2* was inversely related with the ratio of D25-OH to D1-25OH levels (r(2) = 0.42). LVEF was also proportional to the D25-OH/D1-25OH ratio (r(2) = 0.49). Vitamin D deficiency may be associated with cardiac iron uptake and ventricular dysfunction in thalassaemia major patients.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Iron / analysis
  • Iron / metabolism*
  • Iron Overload / etiology
  • Iron Overload / metabolism
  • Liver / chemistry
  • Male
  • Myocardium / metabolism*
  • Stroke Volume
  • Transfusion Reaction
  • Ventricular Dysfunction, Left / etiology
  • Ventricular Function, Left*
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / metabolism
  • Vitamin D Deficiency / physiopathology
  • beta-Thalassemia / complications*
  • beta-Thalassemia / metabolism
  • beta-Thalassemia / physiopathology
  • beta-Thalassemia / therapy

Substances

  • Iron