Translational dermatology in drug discovery: perspectives for integrating humanized xenograft models and experimental clinical studies

Drug Discov Today. 2008 Mar;13(5-6):240-6. doi: 10.1016/j.drudis.2007.10.009. Epub 2007 Nov 26.

Abstract

Application of humanized xenotransplantation disease models and experimental clinical studies in the context of translational research in drug discovery in dermatology is an opportunity to reduce failure due to lack of efficacy in clinical development stage.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Pharmacological
  • Clinical Trials as Topic*
  • Dermatitis, Atopic / drug therapy
  • Dermatitis, Atopic / immunology
  • Dermatologic Agents / immunology
  • Dermatologic Agents / therapeutic use
  • Disease Models, Animal*
  • Drug Design*
  • Humans
  • Mice
  • Mice, SCID
  • Practice Guidelines as Topic
  • Psoriasis / drug therapy
  • Psoriasis / immunology
  • Research Design*
  • Species Specificity
  • Transplantation, Heterologous*

Substances

  • Biomarkers, Pharmacological
  • Dermatologic Agents