Inhibition of I-A expression in rat peritoneal macrophages due to T-suppressor cells induced by Cryptococcus neoformans

D T Masih; C E Sotomayor; L A Cervi; C M Riera; H R Rubinstein

doi:10.1080/02681219180000211

Inhibition of I-A expression in rat peritoneal macrophages due to T-suppressor cells induced by Cryptococcus neoformans

J Med Vet Mycol. 1991;29(2):125-8. doi: 10.1080/02681219180000211.

Authors

D T Masih¹, C E Sotomayor, L A Cervi, C M Riera, H R Rubinstein

Affiliation

¹ Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina.

PMID: 1831842
DOI: 10.1080/02681219180000211

Abstract

The expression of I-A antigen in rat peritoneal cells was significantly reduced during infection with Cryptococcus neoformans. When studying the in vitro action of T-suppressor cells induced by the fungus, or a soluble factor from the T-suppressor cells, a significant decrease in I-A expression by the peritoneal cells was observed. This expression was partially restored by indomethacin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cryptococcosis / immunology*
Cryptococcus neoformans / immunology*
Histocompatibility Antigens Class II / antagonists & inhibitors*
Histocompatibility Antigens Class II / biosynthesis
Indomethacin / pharmacology
Macrophages / immunology*
Peritoneal Cavity / cytology
Rats
T-Lymphocytes, Regulatory / immunology*

Substances

Histocompatibility Antigens Class II
Indomethacin