Objective: In order to determine the inhibitory effects and apoptosis of beta-ionone in human gastric carcinoma SGC-7901 cell line and its possible mechanism.
Methods: The assays of the curves of cell proliferation, cell mitosis, Hoechst 33258 dye stained, emission electronic microscope, and western blotting were employed.
Results: Beta-ionone could inhibit the growth and cell mitosis in SGC-7901 cells. The EC50 value was (174.93 +/- 12.79) micromol/L. Morphology of apoptosis was observed by Hoechst 33258 dye stained and emission electronic microscope. The fragmentation of activated caspase-3 was induced and expression of Erkl/2 protein was decreased in SGC-7901 cells treated with different levels of beta-ionone.
Conclusion: Thus beta-ionone could induce apoptosis in SGC-7901 cells and exactly mechanism needed further to be studied.