Models for non-alcoholic fatty liver disease: a link with vascular risk

Curr Pharm Des. 2008;14(4):378-84. doi: 10.2174/138161208783497705.

Abstract

Non alcoholic fatty liver disease (NAFLD) is often part of the metabolic syndrome which includes central obesity, dyslipidaemia, insulin resistance/type 2 diabetes mellitus and hypertension. In turn, NAFLD may be associated with an increased vascular risk. Several experimental models which express histological steatosis or steatohepatitis with fibrosis have been described. This review identifies those models of NAFLD with features of vascular risk.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Fatty Liver / complications
  • Fatty Liver / metabolism*
  • Fatty Liver / physiopathology
  • Humans
  • Inflammation Mediators / metabolism
  • Risk Factors
  • Vascular Diseases / etiology
  • Vascular Diseases / metabolism*
  • Vascular Diseases / physiopathology

Substances

  • Inflammation Mediators