Multiple sclerosis-like disorder in OPA1-related autosomal dominant optic atrophy

Neurology. 2008 Mar 25;70(13 Pt 2):1152-3. doi: 10.1212/01.wnl.0000289194.89359.a1. Epub 2008 Feb 20.

Authors

C Verny¹, D Loiseau, C Scherer, P Lejeune, A Chevrollier, N Gueguen, V Guillet, F Dubas, P Reynier, P Amati-Bonneau, D Bonneau

Affiliation

¹ Département de Neurologie, Centre Hospitalier Universitaire, INSERM U694, Angers, France.

PMID: 18287570
DOI: 10.1212/01.wnl.0000289194.89359.a1

No abstract available

Publication types

Case Reports

MeSH terms

Adult
Brain / metabolism
Brain / pathology
DNA Mutational Analysis
Diagnosis, Differential
Energy Metabolism / genetics
GTP Phosphohydrolases / genetics*
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics*
Genotype
Heterozygote
Humans
Magnetic Resonance Imaging
Male
Mitochondria / genetics
Mitochondria / metabolism
Mitochondrial Diseases / genetics
Mitochondrial Diseases / metabolism
Mitochondrial Diseases / physiopathology
Multiple Sclerosis / genetics*
Multiple Sclerosis / metabolism
Multiple Sclerosis / pathology*
Mutation / genetics
Nerve Fibers, Myelinated / metabolism
Nerve Fibers, Myelinated / pathology
Optic Atrophy, Autosomal Dominant / genetics*
Optic Atrophy, Autosomal Dominant / metabolism
Optic Atrophy, Autosomal Dominant / pathology*
Optic Nerve / metabolism
Optic Nerve / pathology
Optic Nerve / physiopathology

Substances

Genetic Markers
GTP Phosphohydrolases
OPA1 protein, human