Abstract
Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Acid Sequence
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Female
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Glutamine / chemistry
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Humans
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Male
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Microscopy, Fluorescence
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Molecular Sequence Data
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Peptides / chemistry
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Peptides / pharmacology*
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Proline / chemistry
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Propionibacterium acnes / drug effects*
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Propionibacterium acnes / growth & development
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Saliva / metabolism*
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Salivary Proteins and Peptides / chemistry*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Substances
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Peptides
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Salivary Proteins and Peptides
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Glutamine
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Proline