Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma

Br J Cancer. 2008 Feb 26;98(4):689-92. doi: 10.1038/sj.bjc.6604234. Epub 2008 Feb 5.

Abstract

Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / genetics*
  • Adenocarcinoma / virology
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / virology
  • Case-Control Studies
  • Esophageal Neoplasms / epidemiology
  • Esophageal Neoplasms / genetics*
  • Esophageal Neoplasms / virology
  • Female
  • Genotype
  • Helicobacter Infections / epidemiology
  • Helicobacter Infections / genetics*
  • Helicobacter Infections / virology
  • Helicobacter pylori / genetics*
  • Helicobacter pylori / immunology
  • Humans
  • Male
  • Matrix Metalloproteinase 1 / genetics
  • Matrix Metalloproteinase 12 / genetics
  • Matrix Metalloproteinase 2 / genetics*
  • Matrix Metalloproteinase 3 / genetics
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Surveys and Questionnaires

Substances

  • Matrix Metalloproteinase 3
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 12
  • Matrix Metalloproteinase 1