Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice

Behav Brain Res. 2008 Mar 5;187(2):449-54. doi: 10.1016/j.bbr.2007.10.007. Epub 2007 Oct 13.

Abstract

Different strategies can be used to carry dopamine into the brain such as L-Dopa precursors or galactosilated form of DA (GAL-DA). The aim of this study was to investigate whether GAL-DA would reduce hyperactivity and increase non-selective attention (NSA) in a mouse model of attention deficit hyperactivity disorder (ADHD), as, i.e. C57BL/6 as did in NHE rats. Here we report that GAL-DA increases NSA in a spatial novelty in C57BL/6 mice. They received a single i.p. injection of GAL-DA (10 mg/kg or 100 mg/kg) or equimolar galactose vehicle. Another mouse strain the Swiss albino was introduced as inbred control group. Three hours after last injection mice were tested in a Làt-maze for 30-min. Behaviour was analyzed for horizontal (traveled distance) and vertical activity (orienting frequency and scanning durations) which shares cognitive and non-cognitive nature, respectively. Ten milligram per kilograms of GAL-DA, increases scanning duration in C57BL/6 mice. Thus a low dose of GAL-DA increases NSA without reducing hyperactivity in this mouse model of ADHD.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Attention / physiology*
  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Attention Deficit Disorder with Hyperactivity / metabolism*
  • Disease Models, Animal
  • Dopamine / administration & dosage
  • Dopamine / metabolism*
  • Dose-Response Relationship, Drug
  • Drug Carriers
  • Female
  • Galactose / administration & dosage
  • Galactose / analogs & derivatives
  • Galactose / metabolism*
  • Male
  • Maze Learning / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity / physiology*
  • Species Specificity
  • Statistics, Nonparametric

Substances

  • Drug Carriers
  • Dopamine
  • Galactose