Epilepsy associated with shaken baby syndrome

Childs Nerv Syst. 2008 Feb;24(2):169-72; discussion 173. doi: 10.1007/s00381-007-0493-4. Epub 2007 Nov 20.

Abstract

Object: The shaken baby syndrome (SBS) is an important cause of developmental delay in infants. Epileptic seizures are a common feature of this syndrome. The aim if this study is to analyse the impact of the early and late seizures disorder.

Materials and methods: We have retrospectively reviewed the clinical and electrophysiological findings in a series of 404 children hospitalised with SBS.

Results: In the acute phase, clinical epileptic seizures of various semiologies were found in 73% of the infants. Only 11% of the children had a normal EEG on admission. A poor outcome was found in 88% of the children in case of persisting EEG anomalies despite anti-epileptic treatment with 48% mortality in these patients. The development of refractory epilepsy was also associated with a poor outcome in this series. In fact 96% of the children with seizure recurrence had behavioural problems.

Conclusions: The early recognition and subsequent management of these seizures is vital to prevent further neurological injury. Delayed or recurrent epileptic seizures may occur with a different semiology to the seizures in the acute phase and are also associated with a poor prognosis.

MeSH terms

  • Electroencephalography
  • Epilepsy / etiology*
  • Epilepsy / pathology
  • Epilepsy / physiopathology
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Retrospective Studies
  • Shaken Baby Syndrome / complications*
  • Shaken Baby Syndrome / pathology
  • Shaken Baby Syndrome / physiopathology
  • Tomography, X-Ray Computed