Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma

Int J Med Sci. 2007 Oct 16;4(5):264-6. doi: 10.7150/ijms.4.264.

Abstract

Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.

Keywords: Bone forming cells; Immunohistochemical characteristics; Modified myoepithelial cell; Pleomorphic adenoma; Trans-differentiation.

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Pleomorphic / pathology*
  • Adult
  • Humans
  • Immunohistochemistry
  • Male
  • Osteoblasts / pathology*
  • Salivary Gland Neoplasms / pathology*