Efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, against methicillin-resistant Staphylococcus aureus in a rabbit arthritis model

Antoine Hamel; Jocelyne Caillon; Cédric Jacqueline; Eric Batard; Gilles Potel

doi:10.1016/j.ijantimicag.2007.09.004

Efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, against methicillin-resistant Staphylococcus aureus in a rabbit arthritis model

Int J Antimicrob Agents. 2008 Feb;31(2):158-60. doi: 10.1016/j.ijantimicag.2007.09.004. Epub 2007 Nov 19.

Authors

Antoine Hamel¹, Jocelyne Caillon, Cédric Jacqueline, Eric Batard, Gilles Potel

Affiliation

¹ Université de Nantes, Nantes Atlantique Universités, Thérapeutiques cliniques et expérimentales des infections, EA 3826, UFR Médecine, 1 rue G. Veil, F-44000 Nantes, France.

PMID: 18006281
DOI: 10.1016/j.ijantimicag.2007.09.004

Abstract

We compared the efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, in a rabbit model of methicillin-resistant Staphylococcus aureus-induced arthritis. Vancomycin, alone or in combination with rifampicin, and quinupristin/dalfopristin+rifampicin were significantly more effective than quinupristin/dalfopristin alone.

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology*
Arthritis, Infectious / drug therapy*
Disease Models, Animal
Drug Therapy, Combination*
Methicillin Resistance*
Microbial Sensitivity Tests
Rabbits
Rifampin / pharmacology
Staphylococcal Infections / blood
Staphylococcal Infections / microbiology*
Staphylococcus aureus / drug effects*
Staphylococcus aureus / growth & development
Vancomycin / pharmacology
Virginiamycin / administration & dosage
Virginiamycin / pharmacology

Substances

Anti-Bacterial Agents
Virginiamycin
quinupristin-dalfopristin
Vancomycin
Rifampin