Correlated phenotypic transitions to competence in bacterial colonies

Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Oct;76(4 Pt 1):040901. doi: 10.1103/PhysRevE.76.040901. Epub 2007 Oct 2.

Abstract

Genetic competence is a phenotypic state of a bacterial cell in which it is capable of importing DNA, presumably to improve survival under stress. Motivated by several colony-level known responses, we present a model for the influence of quorum sensing on the transition to competence of B. Subtilis. Coupling to the external signal creates an effective inhibitory mechanism, which results in anticorrelation between the cycles of adjacent cells. We show that this is consistent with recent experimental measurements and propose measurement methods to verify the role of quorum-sensing signals.

MeSH terms

  • Bacillus subtilis / metabolism
  • Bacteria
  • Bacterial Physiological Phenomena*
  • Bacterial Proteins
  • Biophysics / methods*
  • Gene Expression Regulation, Bacterial
  • Models, Biological
  • Models, Chemical
  • Models, Statistical
  • Molecular Conformation
  • Phenotype
  • Pheromones
  • Quorum Sensing
  • Time Factors
  • Transcription Factors / metabolism

Substances

  • Bacterial Proteins
  • Pheromones
  • Transcription Factors