Eleven cases of periodic lateralized epileptiform discharges (PLED) with stroke (9 cases) or transient ischemic attacks are reported. PLEDs are often associated with depression of conscience (81%) or partial pure motor epileptic seizures (90%). PLEDs and seizures seem independent on EEG. Ischemic strokes associated with PLEDs have some characteristic features: old age, vascular risk factors, parieto-occipital areas infarcts and frequent association with TIAs. PLEDs seem to be often associated with watershed infarcts. The relations between PLEDs and cerebral ischemia are discussed.