First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France

Catherine Neuwirth; Eliane Siebor; Frederic Robin; Richard Bonnet

doi:10.1128/AAC.01462-06

First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France

Antimicrob Agents Chemother. 2007 Dec;51(12):4486-8. doi: 10.1128/AAC.01462-06. Epub 2007 Oct 15.

Authors

Catherine Neuwirth¹, Eliane Siebor, Frederic Robin, Richard Bonnet

Affiliation

¹ Laboratoire de Bactériologie, Hôpital Universitaire du Bocage, BP 77908, 21079 Dijon Cedex, France. catherine.neuwirth@chu-dijon.fr

Abstract

We describe the first IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19, which differed from IMP-2 by a single amino acid change (Arg to Ala at position 38). bla(IMP-19) was found within a class 1 integron located on a 35-kb plasmid. This is also the first description of an IMP producer in France.

MeSH terms

Aeromonas / drug effects
Aeromonas / enzymology
Aeromonas / genetics*
Anti-Bacterial Agents / pharmacology
France
Integrons / genetics*
Kinetics
Microbial Sensitivity Tests
Molecular Sequence Data
Plasmids / genetics*
Sequence Analysis, DNA
Substrate Specificity
beta-Lactamases / genetics*
beta-Lactamases / metabolism
beta-Lactams / pharmacology

Substances

Anti-Bacterial Agents
beta-Lactams
beta-lactamase IMP-1
beta-Lactamases

Associated data

GENBANK/EF118171