Cranial sinus thrombosis (CST) is known to be associated with pregnancy and puerperium. A literature review of patients with CST showed a significant proportion of preeclamptic women. The relationship between nephrotic syndrome and hypercoagulability has been well established. We present a 23-year-old gravida III, para I woman with preeclampsia who developed CST. Proteinuria may have played an important pathogenetic role in this setting.