A general strategy for ligation of organic and biological molecules to Dawson and Keggin polyoxotungstates

Kévin Micoine; Bernold Hasenknopf; Serge Thorimbert; Emmanuel Lacôte; Max Malacria

doi:10.1021/ol701701f

A general strategy for ligation of organic and biological molecules to Dawson and Keggin polyoxotungstates

Org Lett. 2007 Sep 27;9(20):3981-4. doi: 10.1021/ol701701f. Epub 2007 Sep 8.

Authors

Kévin Micoine¹, Bernold Hasenknopf, Serge Thorimbert, Emmanuel Lacôte, Max Malacria

Affiliation

¹ Laboratoire de chimie organique (UMR CNRS 7611), Institut de chimie moléculaire (FR 2769), Université Pierre et Marie Curie-Paris 6, 4 place Jussieu, C. 229, 75005 Paris, France.

PMID: 17824707
DOI: 10.1021/ol701701f

Abstract

The copper-catalyzed azide/alkyne cycloaddition (click chemistry) is used for the first time in polyoxometalate chemistry to graft any kind of organics (lipophilic, water-soluble, biologically relevant) to polyoxotungstates to generate hybrids. The method is not limited by solvent matching between the polyoxometallic platforms and the organic substrates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Copper / chemistry
Cyclization
Dimerization
Models, Molecular
Molecular Structure
Organic Chemicals / chemistry*
Polymers / chemistry*
Stereoisomerism
Tungsten Compounds / chemistry*

Substances

Organic Chemicals
Polymers
Tungsten Compounds
polyoxometalate I
Copper