Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North America

Antimicrob Agents Chemother. 2007 Nov;51(11):4209-10. doi: 10.1128/AAC.00560-07. Epub 2007 Sep 4.

Abstract

Five highly amikacin-resistant Acinetobacter baumannii isolates were collected at a medical center in Pennsylvania. The aminoglycoside resistance was due to the production of the 16S rRNA methylase ArmA. Two of the isolates coproduced OXA-23 beta-lactamase and were highly resistant to carbapenems as well. The isolates were genetically closely related by pulsed-field gel electrophoresis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / enzymology*
  • Acinetobacter baumannii / genetics
  • Amikacin / pharmacology
  • Aminoglycosides / pharmacology
  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology
  • Electrophoresis, Gel, Pulsed-Field
  • Humans
  • Methyltransferases / genetics
  • Methyltransferases / metabolism*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • North America
  • RNA, Ribosomal, 16S / metabolism*
  • Sequence Analysis, DNA
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / metabolism

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Carbapenems
  • RNA, Ribosomal, 16S
  • Amikacin
  • Methyltransferases
  • beta-lactamase OXA-23
  • beta-Lactamases

Associated data

  • GENBANK/EU014811