Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome

Haematologica. 2007 Sep;92(9):1277-8. doi: 10.3324/haematol.11341.

Abstract

This report deals with a case of Sézary syndrome, a rare peripheral T-cell lymphoproliferative disorder, in which cytogenetic analysis performed during the disease transformation revealed the presence of a t(9;22) (q34;q11.2) translocation. Molecular analyses identified a new transcript, an e8a4 BCR-ABL fusion mRNA which could be responsible for the disease transformation.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Chromosomes, Human, Pair 22 / genetics
  • Chromosomes, Human, Pair 9 / genetics
  • Fatal Outcome
  • Female
  • Fusion Proteins, bcr-abl / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Sezary Syndrome / diagnosis
  • Sezary Syndrome / drug therapy
  • Sezary Syndrome / genetics*
  • Translocation, Genetic

Substances

  • Fusion Proteins, bcr-abl