We examine the relevance of evidence-based clinical practice (EBCP) in the field of clinical neurosciences, emphasize feasible methods for neurologists to incorporate EBCP into their practice, draw attention to available EBCP resources for the neurosciences, highlight how EBCP has been incorporated into clinical neuroscience training programs, present other EBCP initiatives in neurology, and describe the Mayo Clinic Evidence-Based Clinical Practice, Research, Informatics, and Training (MERIT) Center EBCP programs.