Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Mol Genet Metab. 2007 Nov;92(3):278-82. doi: 10.1016/j.ymgme.2007.06.011. Epub 2007 Aug 2.

Abstract

Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / metabolism
  • Calcium-Binding Proteins / genetics*
  • Calsequestrin
  • Case-Control Studies
  • Denmark / epidemiology
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / genetics*
  • Dyslipidemias / epidemiology
  • Dyslipidemias / genetics*
  • Ethnicity
  • Female
  • Gene Frequency
  • Genotype
  • Glucose Tolerance Test
  • Humans
  • Insulin / metabolism
  • Male
  • Middle Aged
  • Mitochondrial Proteins / genetics*
  • Obesity / epidemiology
  • Obesity / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • White People

Substances

  • Blood Glucose
  • CASQ1 protein, human
  • Calcium-Binding Proteins
  • Calsequestrin
  • Insulin
  • Mitochondrial Proteins