Studies of fat- and water-soluble antioxidants sufficiency (retinol, alfa- and gamma-tocopherols, alfa- and beta-carotene, lycopene, lutein and zeaxanthin, cryptoxanthin, ascorbic and uric acids) and lipid spectrum in patients with cardiovascular disease revealed that blood levels of some carotenoids are directly related to blood levels of vitamin C and to levels of cholesterol of high-density lipoproteins. As total carotenoids content in blood decreased lower than 80 microg/dl, the significant raise of average concentration of urates (p=0.012) and significant decrease of ascorbic acid (p=0.007) content in blood of the patients were observed.