Necrotizing arteritis in acute poststreptococcal glomerulonephritis: report of a recovered case

J Pediatr. 1977 Aug;91(2):228-32. doi: 10.1016/s0022-3476(77)80817-2.

Abstract

A patient with biopsy documented acute poststreptococcal glomerulonephritis and arteritis recovered completely with supportive therapy. Illness was preceded by group A streptococcal pharyngitis. At the time of presentation, serum creatinine concentration was 11.5 mg/dl. Serum cryoglobulins containing IgG and C3 were present. The first biopsy, performed during the acute illness, contained glomeruli with typical features of acute PSGN. Medium-sized arteries had extensive necrosis and leukocytic infiltration, and contained IgG, C3, and fibrin. Glomerular filtration rate returned to normal within three weeks; proteinuria cleared by three months, and microscopic hematuria by 11 months. Renal biopsy one year later showed minimal mesangial hypercellularity and no arteritis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adolescent
  • Biopsy
  • Complement C3 / analysis
  • Cryoglobulins / analysis
  • Fluorescent Antibody Technique
  • Glomerulonephritis / immunology*
  • Glomerulonephritis / pathology
  • Humans
  • Immunoglobulin A / analysis
  • Immunoglobulin G / analysis
  • Kidney Glomerulus / immunology
  • Kidney Glomerulus / pathology
  • Male
  • Polyarteritis Nodosa / immunology*
  • Polyarteritis Nodosa / pathology
  • Streptococcal Infections / immunology*
  • Streptococcal Infections / pathology
  • Streptococcus pyogenes

Substances

  • Complement C3
  • Cryoglobulins
  • Immunoglobulin A
  • Immunoglobulin G